DNA Damage, Fruits and Vegetables and Breast Cancer Prevention
Abstract
The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer. The rationale that underlies the work proposed is based on evidence that the occurrence of DNA mutations are essential steps in carcinogenesis and that these mutagenic events can result from oxidative stress, even in the absence of exogenous carcinogens. The effects of consuming a recipe-defined diet designed to provide three (control) or ten (intervention) servings of fruits and vegetables per day for a total of 8 weeks on measures of oxidative damage to DNA and lipids is being determined. During this reporting period, 160 individuals interested in the project were identified as eligible to participate. Of these candidate participants, 120 actually began the study and 92 have completed the study. Accrual to the study continues with the objective of completing accrual goals by April 2002. Evaluation of biological samples and dietary records is ongoing. However, since formal interim data evaluations are not a component of the analysis plan, no additional results are available.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA400024
Entities
People
- Henry J. Thompson