4,4' Methylenedianiline (MDA) for General Industry
Abstract
On August 10, 1992, the Occupational Safety and Health Administration (OSHA)issued a final standard on the regulation of exposure to 4,4' Methylenedianiline (MDA) in Volume 29 of the Code of Federal Regulations (29 CFR) Part 1910.1050. Coverage of this standard applies to general industry (primary chemical manufacture, reprocessing, filament winding, potting, and encapsulating) and to the maritime industry. OSHA issued a separate standard for MDA exposure in the construction industry in 29 CFR 1926.60. In September 1983, OSHA and the Environmental Protection Agency (EPA) jointly published an advanced notice of proposed rulemaking (ANPR). EPA later issued a notice under section 4(f) of the Toxic Substances Control Act (TSCA) indicating that exposure to MDA presents a significant risk to humans as a carcinogen. EPA based this conclusion on studies performed by the National Toxicology Program (NTP) and on data collected by the Oak Ridge National Laboratories that supported findings of MDA as a carcinogen in test animals. The ability of MDA to induce tumors in animals-suggestive evidence that MDA may induce bladder tumors in humans and data indicating that MDA interacts with genetic material led to the conclusion that this chemical is an animal carcinogen and is a possible carcinogen to humans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1993
- Accession Number
- ADA400442
Entities
Organizations
- United States Department of Labor