Regulation of I Transport in Breast Cancer Cell Lines
Abstract
Like thyroid tissue, breast tissue and some breast cancers are able to accumulate iodide. Iodide accumulated by the lactating breast is secreted into the milk. Iodide is then used by the nursing newborn for the biosynthesis of thyroid hormones, which are essential for the newborn's development. The capacity to accumulate iodide has been used successfully for over 50 years in the treatment of thyroid cancer by administration of radioiodide to patients. It is possible that iodide accumulation may also be used as a potential aid for diagnosis and treatment of breast cancer. The Na(+)/I(-) symporter (NIS) mediates active iodide accumulation in breast and thyroid. Based on my preliminary studies in thyroid NIS, we are currently studying the regulatory mechanisms of NIS in breast cell lines. We are studying NIS regulation at both the transcriptional and post-transcriptional levels, including the role of phosphorylation in the regulation of NIS activity and its targeting to the cell surface in breast cell lines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA400482
Entities
People
- Claudia Riedel
- Nancy Carrasco
Organizations
- Albert Einstein College of Medicine