Breast Reconstruction Using Tissue Engineering
Abstract
This is a progress report for the development of tissue engineering strategies for breast reconstruction following tumor resection: * Task 1, a long-term (12 month) in vivo study using a rat model, was initiated at the end of Year 1 of this grant. The study was completed in this Year 2 cycle of the grant. Biodegradable polymer scaffolds were fabricated, preseeded with preadipocytes (PAs), and implanted subcutaneously for 1-12 months. Quantitative histometric analysis was developed to assess the study. * The effect of hypoxia on PA viability was completed (in vivo design constraint) * The mechanisms and adhesion molecules involved in PA-material interactions is 90% complete (important for rational modification of polymer surfaces) * The development of a large animal model (pig) was initiated to address questions raised in the rat model. * The development of breast-shaped scaffolds has progressed to a 2% generation virtual model of the breast based on patient-specific data. * New polymer hydrogels are being investigated for adipose tissue engineering strategies. * Support for a PhD and BS candidate as well as two technicians was provided. Academic outcome metrics (publications, presentations, etc) have been positive.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA400643
Entities
People
- Charles W. Patrick Jr.
Organizations
- The University of Texas MD Anderson Cancer Center