Comparison of Bubbler Versus Sorbent Tube Sampling for the Analysis of GB (Sarin) Vapor for Inhalation Toxicology
Abstract
Previous GB (sarin) inhalation studies have typically used solvent bubblers to determine vapor concentrations, particularly at lethal exposure levels. However, investigations for future low-level GB exposures necessitate the need for a sampling system more sensitive than bubblers. To meet this requirement, an automated sorbent tube/thermal desorption system was tested and validated against sample bubblers. Data was obtained during an existing GB inhalation exposure study with vapor concentrations ranging from 2 to 7 mg/m3 GB. Samples from both techniques were drawn from the same inhalation chamber and quantitatively analyzed by gas chromatography for GB vapor. Concentrations derived from each sampling method were compared against each other and statistically evaluated. A paired t-test of the data showed no statistical difference between the two methods at the 95% confidence interval. Future applications of the sorbent tube sampler would include monitoring GB levels approaching the TLV-TWA of 0.0001 mg/m3.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2002
- Accession Number
- ADA400830
Entities
People
- H. Dupont Durst
- J. S. Anthony
- Leonard C. Buettner
- Robert J. Mioduszewski
- William T. Muse Jr.
Organizations
- Edgewood Chemical Biological Center