Malaria Genome Sequencing Project
Abstract
The objectives of this 5-year Cooperative Agreement between TIGR and the Malaria Program, NMRC, were to: Specific Aim 1, sequence 3.5 Mb of P. falciparum genomic DNA; Specific Aim 2, annotate the sequence; Specific Aim 3, release the information to the scientific community. Two additional Specific Aims were added to the Cooperative Agreement: Specific Aim 4, sequencing of P. yoelii to 3x coverage; Specific Aim 5, sequencing of P. vivax to 3x coverage. To date, we have published the first complete sequence of a malarial chromosome (P. falciparum chromosome 2), have sequenced and have nearly completed the sequences of P. falciparum chromosomes 10, 11, and 14. A plan for joint annotation and publication of the P. falciparum genome with the Sanger Centre and Stanford University was prepared and implemented. Publication of the P. falciparum genome sequence is anticipated in late 2002. In addition, we completed sequencing of the rodent malaria P. yoelii to 5X coverage and have begun the sequencing of P. vi vax to 5X coverage. Discussions with the Malaria Program, NMRC aimed at development of a program to use genomics and functional genomics to accelerate vaccine research are in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA400972
Entities
People
- Malcolm J. Gardner
Organizations
- J. Craig Venter Institute