Mammary Gland Ontogeny and Neoplasia in Oxytocin Deficient Mice

Abstract

The neurohypophysial peptide oxytocin (OT) is synthesized within the paraventricular and supraoptic nuclei (PVN and SON) of the hypothalamus and stored within the posterior pituitary gland. The mammary gland is one of the major targets for OT's effects. During lactation suckling by the young stimulates release of OT from the posterior pituitary gland into the peripheral circulation. OT attaches to its receptor on the mammary myoepithelial cell and elicits contraction and the ejection of milk, In addition to its contractile effects, OT has been reported to enhance myoepithelial cell differentiation and proliferation in murine mammary organotypic cultures.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA401201

Entities

People

  • Janet A. Amico

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Vessels
  • Brain
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Endocrine Glands
  • Glands
  • Mammary Glands
  • Neoplasms
  • Ontogeny
  • Pituitary And Hypothalamic Hormones And Analogues
  • Pituitary Glands

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular Biology and Genetics
  • Neuroscience