Mammary Gland Ontogeny and Neoplasia in Oxytocin Deficient Mice

Abstract

Mice in which the gene for oxytocin has been deleted (OT -/- mice) have been used to study mammary gland development in the absence of this hormone. These mice, derived from 129 52/B16 background, have no processed OT and thus the mammary gland is not exposed to OT at any stage of development. The animals are being studied to determine if any morphological changes occur throughout the life cycle of mouse mammary gland development in the absence of this hormone. In addition, we are also testing whether deficiency of OT and the absence of its effects upon the mammary gland, may in part, predispose the breast to neoplastic changes. To date we have sacrificed both virgin and parous (OT -/-) and age-matched wild types cohorts (OT +/+) throughout the life span of the animals (3 mo to 24 mo). Histological analysis of these mammary tissues is currently in progress.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA401203

Entities

People

  • Janet Amico

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Vessels
  • Brain
  • Breast Cancer
  • Cells
  • Connective Tissue
  • Cycles
  • Deficiencies
  • Endocrine Glands
  • Glands
  • Hormones
  • Mammary Glands
  • Neoplasms
  • Ontogeny
  • Pituitary And Hypothalamic Hormones And Analogues
  • Pituitary Glands
  • Tissues

Fields of Study

  • Biology

Readers

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