Functional Analysis of TGFRP, a Putative Angiogenic Factor, in Breast Carcinogenesis

Abstract

The primary goal of this project is to test the hypothesis that a newly identified protein, TGFRP, functions as an angiogenic factor to promote tumor progression and metastasis. As discussed in the research proposal, our preliminary results strongly support this postulation. With the generation of additional substantial experimental evidence from the proposed studies, we wish to firmly establish a role for TGFRP in the pathological process of breast carcinogenesis and lay the foundation for the development of novel therapeutics for the treatment of breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA403320

Entities

People

  • Xiao-Fan Wang

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Angiogenesis
  • Biomedical Research
  • Blood Vessels
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cells
  • Endothelial Cells
  • Functional Analysis
  • Growth Factors
  • Migration
  • Neoplasms
  • North Carolina
  • Proteins
  • Tumor Cell Line

Readers

  • Combustion Dynamics and Shock Wave Physics.
  • Oncology (Cancer Research).
  • Theoretical Analysis.