Molecular Markers in Hereditary Breast Cancer
Abstract
The promise of research into breast cancer genetics is that it will provide us with new insights into the etiology of breast cancer that can be translated to strategies for early diagnosis and treatment for the larger population of women who develop breast cancer without having a genetic predisposition. An academic award represents an outstanding opportunity for me to critically appraise the emerging role of genetics in clinical breast cancer care and forge new avenues of research. Toward this goal, I plan to accomplish the following during the award period: 1) perform a thorough review of the cytogenetic and molecular genetics literature to identify potential chromosomal regions that may harbor genes whose abnormal function is critically involved in the development of breast cancer. 2) develop a robust panel of markers that can be used for clinical correlative studies of hereditary breast cancers. 3) develop a tissue repository composed of biological specimens from 500 patients with inherited breast cancer (e.g fresh frozen tumor specimens, or paraffin embedded tumor specimens and normal blood lymphocytes, DNA and sera whenever possible). These studies will lead to an improved understanding of the biology of breast cancer which will ultimately translate into more effective therapies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA403325
Entities
People
- Olufunmilayo I. Olopade
Organizations
- University of Chicago