Magnetic Resonance Spectroscopy of Breast Disease
Abstract
We have developed a unique magnetic resonance imaging multi voxel pulse sequence producing spectroscopic images of key metabolites found in breast cancer, and validated our work with in vitro spectra and pathology. We have shown that choline peaks are often present in breast cancer, and that our MRS sequence was unaffected by intravenous contrast, increasing its clinical utility as an adjunctive study to clinical breast MRI scans. However, MRS may have a major limitation in that specific tumor histologies that have dispersed cells, such as invasive carcinomas with some invasive lobular carcinoma features may not show choline peaks. Technical developments to date have significantly contributed towards the goal of making MR spectroscopic imaging a clinically useful procedure that could be implemented at the time of a contrast-enhanced MRI scan. Important applications for this technique include distinction of a breast cancer recurrence from a post-biopsy scar within 24 months of initial breast cancer treatment, evaluation of unexpected enhancing lesions on contrast-enhanced scans obtained for a specific target lesion, and to identify additional cancers during breast cancer staging and preoperative surgical planning (lumpectomy vs mastectomy)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA403388
Entities
People
- Debra M. Ikeda
Organizations
- Stanford University