Tumor Suppressors and Breast Cancer
Abstract
Mutations in BRCA2 are responsible for about 35% of familial breast cancers and also a proportion of familial ovarian cancers. Both BRCA2 and BRCAl proteins were shown to have transcriptional activation domains and also shown to be associated with RNA polymerase suggesting that these proteins may function as transcriptional factors and have a role in the regulation of transcription. Recent studies on enzymes responsible for histone acetylation and deacetylation revealed that some of the transcriptional factors function as histone acetyl transferases. Since BRCA2 showed transcriptional activation properties, we tested whether BRCA2 is associated with histone acetyltransferase. Our results suggested that BRCA2 is associated with histone acetyltransferase (HAT) activity. We propose to test whether HAT activity plays a role in tumor suppressor activity of BRCA2. We plan to identify the factors that associate with BRCA2 and study the role of these protein-protein interactions in the biochemical and biological properties of BRCA2. We intend test whether transcriptional activation function has any role in the tumor suppressor activity of BRCA2. We intend to identify the BRCA2 target genes and study (in future) their role in the tumor suppressor activity of BRCA2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA403397
Entities
People
- E. Shyam
- P. Reddy