EOX for Noninvasive Physiologic Monitoring
Abstract
An EOX is an instrument that scans low-powered lasers into a subject's eye and spectroscopically determines oxygen saturation of blood within the retinal veins and arteries. Pilot animal studies performed by our group with an EOX indicate that retinal venous oxygen saturation is a sensitive indicator of blood loss. We have developed a 2-D scanning EOX which is readily reconfigured to operate at various wavelengths, and to use confocal techniques and polarization to constrain the potential sources of collected light. Thus, the instrument is being used to fully explore the physics of retinal oximetry, with the goal of a calibrated instrument. The parallel development of a model eye allows for rapid verification of EOX modifications on a test object with far fewer unknowns. Data collection across varying oxygen saturation, hemoglobin concentration, vessel diameter, fund us reflectivity, and filtering configurations permits analysis of the contributions of each of these components to the actual complex measurement. This data has been critical to improving our understanding of the algorithms necessary for calibrating the EOX. Finally, a human pilot study performed on subjects in a Lower Body Negative Pressure experiment was also accomplished, successfully acquiring data on 15/15 subjects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 28, 2002
- Accession Number
- ADA403422
Entities
People
- Art Lompado
- Lloyd W. Hillman
- Patrick J. Reardon
Organizations
- University of Alabama in Huntsville