An LOH Study of Chromosome 8 in Multiple Prostate Cancer Sibships

Abstract

This study is designed to identify one or more prostate cancer (CaP) tumor suppressor genes (TSO) on chromosome 8 by assessing the distribution of loss of HETEROZYGOSITY IN BROTHERS FROM MULTIPLEX SIBSHIPS. A strong linkage signal has been demonstrated in these families. The differential pattern of linkage disequilibrium between affected men and controls will be used to further narrow the region and the potential for epistatic interaction between a TSG and two non-chromosome S putative CaP susceptibility genes (HPC2/ELAC2 and the androgen receptor) will be assessed with methods currently under development. Scope: The region of interest is the entire short arm of chromosome S and a region from approximately D8S2324 to D8S592 on 8q. Major Findings: Although the genotyping is not yet complete, we find levels of LOH in our multiplex sample comparable to levels reported among unrelated men. The region of greatest LOH stretches from D8S277 to D8SlS25 and corresponds to the peak linkage signal.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA403667

Entities

People

  • Brian K. Suarez

Organizations

  • Washington University in St. Louis

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Amino Acids
  • Androgen Receptors
  • Androgens
  • Cells
  • Cellular Structures
  • Chemistry
  • Chromosomes
  • Computer Programs
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Neurodegeneration
  • Prostate Cancer
  • Sickle Cell Anemia

Readers

  • Molecular and genetic basis of cancer.