Mouse Mammary Cancer Models - Mechanisms and Markers
Abstract
We have generated and characterized several mouse models to better understand the role of breast cancer associated genes in an experimentally manipulable context. In one model, we have examined Wnt-1 transgene-initiated mammary adenocarcinomas in the presence and absence of p53. In this model, we have identified seven differentially expressed genes which are dependent on p53 status. All of these genes are relevant either to cell cycle control or differentiation state and may be partially responsible for the p53-dependent difference in biological attributes. In a second set of studies, we have shown that Brca2 heterozygosity in a p53 null background accelerates mammary tumorigenesis compared to their Brca2 wild type counterparts, suggesting that mere reduction in Brca2 dosage is sufficient to accelerate tumorigenesis. Finally, we are studying the effects of a novel p53 target gene, Wip1, for its role in mammary tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA404557
Entities
People
- Lawrence A. Donehower
Organizations
- Baylor College of Medicine