The Role of Histone Deacetylase and DNA Methylation in Estrogen a Expression in Breast Cancer

Abstract

The proposal tests the hypothesis that histone deacetylase activity contributes to the transcriptional repression of the methylated estrogen receptor a (ER) gene. It further postulates that inhibition of histone deacetylase (HDAC) and DNA methylation may act together to reactivate the ER gene. Studies to date show that the HDAC inhibitor trichostatin A, can reactivate ER expression in ER- negative breast cancer cell lines. Combined studies with HDAC inhibitors and demethylating agents are in progress.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2001
Accession Number
ADA404589

Entities

People

  • Xiaowei Yang
  • Yi Huang

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Birds
  • Breast Cancer
  • Cancer
  • Carcinogens
  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Colon Cancer
  • Enzyme Inhibitors
  • Gene Expression
  • Genetics
  • Neoplasms
  • Oncology

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.