Mammalian Homologs of Yeast Checkpoint Genes

Abstract

We hypothesize that components of DNA-related checkpoint pathways in addition to members of the ATM protein/lipid kinase family are conserved in all eukaryotes. This is based on functional similarities in the pathways and the conservation between evolutionarily disparate budding and fission yeasts. Work described herein discusses a new model for ATM-dependent regulation C the effector kinase Chk2. We show that DNA damage induces oligomerization of Chk2. Chk2 dimerization can be mediated by an interaction between an FHA domain on one Chk2 molecule and a phosphopeptide on another. The significance of this interaction for DNA damage-dependent regulation of Chk2 is discussed.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA404591

Entities

People

  • David F. Stern

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Bacteria
  • Breast Cancer
  • Cell Physiological Processes
  • Cell-Free System
  • Cells
  • Chemistry
  • Enzyme Inhibitors
  • Eukaryotes
  • Fungi
  • Health Services
  • Materials
  • Metabolic Diseases
  • Neoplasms
  • Network Protocols
  • Neutral Amino Acids
  • Proteins

Fields of Study

  • Biology

Readers

  • Materials Science and Engineering.
  • Molecular Biology and Genetics
  • Molecular Genetics