Development and Characterization of Transgenic Mice with Mammary Gland Specific Expression of the Tumor Suppressor

Abstract

Tumor suppressor MMACl/PTEN/TEPl is considered related with breast cancer formation or progression due to a collective evidence of mutant MMAC 1 in various advanced cancers, especially breast carcinoma. Our preliminary data as well as results of most recent study have provided further evidence of MMAC 1 regulation on PI3K pathway signaling and cell activities, such as cell growth and survival. Our observation of differential modulation of MMAC1 on protein tyrosine phosphorylation in cells indicates a complex role of MMAC1 in multiple cell signals. Thus, the established MMAC 1 transgenic mice model will undoubtedly help to determine the role of MMACl in mammary development and tumorigenesis in vivo.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA404605

Entities

People

  • Muling Mao

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Electronic Mail
  • Genes
  • Genetics
  • Growth Factors
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Suppressors
  • Tissues

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.