Preclinical Mouse Models of Neurofibromatosis

Abstract

This is the first annual report from a Consortium of investigators who are working together to develop, characterize and utilize strains of mice that accurately model tumors that develop in persons with NFl and NF2. In the first year of its existence, this Consortium has made progress in accomplishing its primary goal of generating and characterizing mouse models of NFl and NF2-associated tumors for biologic and preclinical therapeutic trials. A number of novel strains have been developed, and innovative strategies are being deployed to make optimal use of these resources. The investigators have collaborated closely and have shared expertise and reagents extensively. This NF Consortium has been admitted to the Moue Models of Human Cancer Consortium of the National Cancer Institute and is participating fully in the activities of the group.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADA404608

Entities

People

  • Andrea I McClatchey
  • Kevin M. Shannon
  • Luis F. Parada
  • Marco Giovanni
  • Tylr Jack

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Blood
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Cytoskeleton
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Neuromuscular Diseases
  • Peripheral Nervous System

Readers

  • Computational Modeling and Simulation
  • Neurological Diseases/Conditions/Disorders
  • Technical Research and Report Writing.