Vaccine Development Against Novel Breast Cancer Antigens
Abstract
The initial proposal was to produce multiple antigens; to use oxidised mannan as a delivery system and finally to see the effect of single and multiple other antigens in experimental tumours in mice. A number of the antigens have been made including: a) MUC 1 - glycosylated; full length MUC 1 lacking VNTR; mutant forms of MUC 1; b) nm23; c) Claudin 7 peptide epitopes synthesised; d) we are obtaining the Her2/neu protein. Secondly, we have expanded the delivery system to not only include mannan, but also include particles capable of targeting dendritic cells. Finally, several tumor models are currently in use:- a) Tumor models are MUCi transgenic models; b) mouse tumours expressing the antigens and c) MCSF-7-ras growing in SCID mice which will adoptively receive cells; d) comparison of the mannan - DC targeting vectors and DNA will be done to conclude this project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA404639
Entities
People
- Ian Mckenzie