Development of a Novel Vaccine with Fusions of Dendritic and Ovarian Cancer Cells from Patients

Abstract

Ovarian carcinoma cells from patient were fused to autologous and allogeneic dendritic cells (DC). The fusion cells co-expressed tumor-associated antigens derived from ovarian carcinoma cells and DC-derived co-stimulatory molecules. Fusion cells retained the functional potency of DC and stimulated autologous T cell proliferation in vitro. These T cells derived from patients with metastatic ovarian cancer induced MHC class 1-restricted lysis of autologous ovarian tumor cells, but not monocytes allogeneic ovarian carcinoma cells or MUC1 positive tumor cell lines. These findings indicate that fusions of human ovarian cancer cells with autologous or allogeneic DC induce specific antitumor immune response against autologous ovarian cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2001
Accession Number
ADA404671

Entities

People

  • Jianlin Gong

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Cancer
  • Cardiovascular System
  • Cell Line
  • Cells
  • Cultured Cells
  • Immunomodulation
  • Lymphocytes
  • Molecules
  • Mononuclear Phagocyte System
  • Neoplasms
  • Ovarian Cancer
  • T Lymphocytes
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech