Roles of the Mitotic Checkpoint Regulators Pin1 and Pin2 in Breast Cancer
Abstract
Our laboratory has recently identified a new protein, Pin1, that is involved in checkpoint control. Pin1 interacts with mitotic phosphoproteins and helps to orchestrate the timing of mitotic events. We found that Pinl is highly overexpressed in breast cancer. Pinl levels correlate with the levels of cyclin Dl protein as well as with cyclin Dl mRNA levels. We have shown that Pinl is a transcriptional acitvator of cyclin Dl. Activation occurs indirectly through the binding of phosphorylated c-jun. Our data indicate that Pinl may contribute to neoplastic transformation by causing accumulation of cyclin Dl.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA404683
Entities
People
- Gerburg M Wulf
- Kung P. Lu
Organizations
- Beth Israel Deaconess Medical Center