Roles of Steroid Receptor Coactivators in Breast Cancer

Abstract

The purpose of this study is to determine whether the expression of SRC-l family members (SRC-l, TIF2, and AIB1) is altered during breast cancer progression. The scope of the research is assessing the expression of SRC-1 family members during breast cancer progression using breast cancer tissue and adjacent normal tissue obtained from Indiana University Tissue Procurement Facility. In addition, adenovirus expressing AIB1 has been constructed for testing the functions of AIB1. We found that AIB1 protein is overexpressed in human breast cancer specimens, as compared to adjacent normal breast tissue. Comparison of AIB 1 expression with tumor grading, staging and other pathological results are ongoing. This study suggests that alteration of AIB1 expression is likely to play important role in breast cancer cell proliferation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2001
Accession Number
ADA404705

Entities

People

  • Meei-huey Jeng

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Biological Staining And Labeling
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Glands
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Procurement
  • Tissue Culture
  • Tumor Cell Line
  • Universities
  • Viruses

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology and Biomarker-Based Cancer Detection.