An Experimental System to Evaluate LOH in Prostate Cancer
Abstract
Our goal is to help define the human genes that are associated with prostate cancer. One of the steps in development of prostate cancer may be the loss of important genes called tumor suppressor genes. These genes suppress the formation of tumors. When they are not functional, tumor forming cells are no longer inhibited and cancers may develop. Identification of these genes is a complex process that relies on sorting through may different patient's tumor samples and looking for changes in number of genes. When a researcher detects a gene loss there is potential identification of a tumor suppressor gene. One problem with this approach is that there is no way to test these genes fro actual tumor suppressor activity. The purpose of this grant is to develop the technology of directly evaluating portions of chromosomes and genes for their role as tumor suppressors. Ultimately, and clearly beyond the scope of this granting period, we hope this will lead to new treatments for prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA404716
Entities
People
- William M. Strauss