Androgen and Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk
Abstract
This project will assess the association between breast cancer risk and polymorphisms of the androgen receptor (AR) and vitamin D receptor (VDR) genes among subjects in a population-based case-control study in Sweden. From this study population, breast cancer cases and control women have been randomly selected for genomic DNA analysis. The collection of blood or tissue specimens has been funded from other sources; this award is for the measurement of the AR and VDR polymorphisms on 300 cases and 300 controls who never used HRT, and a similar number of cases and controls who used HRT for 4 years of more. Information on these polymorphisms will be incorporated into the established subject database, and odds ratios summarizing the associations with breast cancer risk will be computed. In the previous years of the project, the work was organized, a tracking database for subject recruitment and specimen accrual was built, and recruitment into the molecular epidemiology study completed. The laboratory investigators have completed DNA extraction and amplification from virtually all available specimens, and have as well completed most of the assays. All laboratory analyses will be completed in December 2001. Under a no-cost extension, data analysis and reporting will be completed in 2002.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA404775
Entities
People
- John A. Baron
Organizations
- Dartmouth College