Signal Transduction in Regulation of Autocrin HGF Expression in Breast Cancer Metastasis
Abstract
Increased expression of HGF and its receptor Met in breast cancer has been identified as a possible independent predictor of recurrence in breast cancer patients. In contrast, most non-malignant epithelial cells express Met but not HGF. Thus, the change in regulation of HGF expression may be a key step in breast cancer progression. In this project, Dr. Hung has demonstrated a co-operative effect of c-Src and Stat3 in the activation of HGF expression in carcinoma as well as epithelial cells. Changes in c-Src kinase activation affect Stat3 activity through its tyrosine phosphorylation and DNA binding activity to specific Stat3 consensus sites on the HGF promoter. These results suggest tumor specificity in the transcriptional regulation of HGF expression in carcinoma cells, and could thus lead to novel strategies for the design of low molecular weight antagonists to inhibit tumor metastasis. Dr. Hung departed from this laboratory to take up a new position at the Sunnybrook Health Science Centre, University of Toronto. This PDF training award has recently been modified to extend the term, without any additional lands, from 1 July 0 1 to 1 July 02. All other terms and conditions of this award remain the same. There is no new progress since the last annual report was filed. We are aggressively recruiting for a new candidate for this PDF position.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA404779
Entities
People
- Bruce E. Elliott
- Wesley L. Hung
Organizations
- Queen's University