Mechanisms of Breast Carcinogenesis Involving Wild-Type p53
Abstract
Genetic alteration of p53 resulting in loss-of-function is a common event in many human cancers. In contrast, the majority of human breast carcinomas express a wild-type p53 protein. p53 is a transcription factor which exerts its effects by regulating the expression of particular target genes. Alterations in the expression of factors that regulate p53-dependent transcription may contribute to breast carcinogenesis in which the p53 itself is wild-type. As an approach to identify such factors, three p53-dependent target genes have been identified in which additional sequence elements besides p53 binding sites are involved in the transcriptional response to p53.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA405173
Entities
People
- James Manfredi
Organizations
- Icahn School of Medicine at Mount Sinai