Soy Metabolites, Isoflavones in Cell Growth and Apoptosis

Abstract

The purpose of our investigation was to elucidate the molecular mechanism(s) by which genistein elicits its biological effects on non-tumorigenic and tumorigenic breast epithelial cells. We have completed all our tasks as planned and our major findings are: (a) that genistein inhibits cell cycle by modulating genes that are important cell cycle regulators, (b) that genistein induces apoptotic cell death in breast cancer cells irrespective of their status of estrogen receptor positivity, (c) that genistein elicits differential effects between non-tumorigenic and tumorigenic breast epithelial cells, and (d) that genistein also down regulate NF-kB in breast epithelial cells and that this effect of genistein may be due to down regulation of Akt signaling (this aspect is currently being pursued in a pending grant application to the Department of Defense).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2002
Accession Number
ADA405198

Entities

People

  • Fazlol Sarkar

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Colon Cancer
  • Department Of Defense
  • Epithelial Cells
  • Materials
  • Metabolites
  • Neoplasms
  • Regulations
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.