Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees With Very High Bone Density
Abstract
The proposed work focuses on identifying the genes and their function that are involved in the acquisition of peak bone density and also the genes and their function that regulate the anabolic skeletal response to mechanical stress. To gain information about genes regulating bone density, we have identified three large pedigrees in which there are subjects with very high bone density. The long term goal will be to perform genome-wide linkage analyses to ultimately identify the gene (and its corresponding function) responsible for the high bone density in each of the three pedigrees. The proposed work on mechanical strain involves a QTL analysis of mouse periosteal bone formation in response to jump training. During the first twelve months of the funding period, we proposed several technical objectives for the studies mentioned above. As disclosed in this progress report, we have successfully accomplished all of the specific objectives outlined for the first award year in addition to completing many additional objectives above and beyond those specific objectives outlined in the original proposal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2002
- Accession Number
- ADA405304
Entities
People
- David J. Baylink