Non-Invasive Determination of Breast Cancer Oxygen Tension by F-19 NMR and Breast Cancer Physiology in Response to Radiotherapy
Abstract
The goals of this Predoctoral Traineeship were two-fold: 1) To provide me with the solid and extensive training and valuable experience in a modern NMR laboratory for a career as a clinical medical physicist and a breast cancer research scientist; 2) To develop and investigate a non-invasive technique of measuring oxygen tension in breast cancer based on 19-F MRI of hexafluorobenzene(HFB) For the past three years, I have learned tumor biology, tumor histology, tumor modeling, surgical techniques for implanting tumors, electronic techniques of designing, constructing, and testing MRI RF coils, MRI data acquisitions, Computer programming, digital signal and image processing, near-infrared spectroscopy (NIRS) , and operation of advanced medical systems and instruments. In addition, I designed and constructed a double-tuned (19-F - 1-H) birdcage resonator and a switchable slotted tube resonator. I wrote several computer programs for acquiring and processing MRI and NIRS data. I developed a mathematical model for describing tumor hemodynamics following physiological perturbations, and a second mathematical model for computing tumor oxygen consumption following KC1-induced cardiac arrest using NIRS. I found that the HFB signal intensity decays exponentially with a typical biological half-life ranging from T(sub 1/2) = 700 to 1200 minutes. The global arid regional clearance and redistribution of HFR within the tumors did not interfere with 19-F MRI oximetry. The local response to respiratory challenge depended strongly on initial baseline pO2 in breast tumor NF13762, with voxels of high baseline 502 showing significant changes in pO2, while voxels of low baseline pO2 showed small changes. Irradiation delayed tumor growth and caused changes in tumor oxygenation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA405356
Entities
People
- Julin Song
Organizations
- University of Texas Southwestern Medical Center