IGF-1, 1,25 (OH) Vitamin D, and Prostate Cancer
Abstract
The scientific rationale for this Idea Grant was to clarify whether modifiable, mainly nutritional, influence levels of IGF-l, IGFBP-3, 1,25 (OH)2 vitamin D (l,25(OH)2D), and 25(OH)vitamin D. High levels of IGF-l and low l,25(OH)2D have been shown to be related to elevated risk of prostate cancer. Some dietary factors that hypothetically impact on these serological factors, including total energy intake, calcium intake and protein intake, have been associated with prostate cancer risk. In the current study, none of the hypothesized factors showed correlations with l,25(OH)2D in 630 men. These results do not support our original hypothesis that 1,25 vitamin D is an important mediator of risk of several dietary risk factors of prostate cancer. We were able to demonstrate that intake of protein and minerals influence IGF-l levels moderately in 751 men, but men with high intakes of protein and minerals were not at higher risk of prostate cancer relative to men with low intakes of these. These findings suggest that the range of dietary influences on prostate cancer in generally well-fed populations is unlikely to have a major impact on risk of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA405364
Entities
People
- Edward L. Giovannucci
Organizations
- Harvard T.H. Chan School of Public Health