Identification and Characterization of Transcriptional Intermediary Factor Involved in Androgen-Independence of Prostate Cancer
Abstract
During the second year of this postdoctoral training award, I continued to characterize the involvement of two proteins, NF-kB and BRCA1 that were identified in the first year of training, in androgen receptor transcription activity. Because they regulate expression of the PSA gene that is tightly regulated by androgen receptor, they are potential transcriptional intermediary factors for androgen receptor. I have successfully identified BRCA1 as a transcriptional co-repressor for androgen receptor. I demonstrated that NF-kB regulates expression of the PSA gene by direct binding to an enhancer of the PSA gene and ruled out the original hypothesis that NF-kB is a transcriptional intermediary factor for androgen receptor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA405391
Entities
People
- Charlie D. Chen
Organizations
- University of California, Los Angeles