Differentially Expressed Genes in Human Prostatic Carcinoma

Abstract

The molecular genetic basis of prostate cancer is poorly understood, that hampers optimal diagnosis, prognosis, and therapy of patients with prostate cancer. We originally proposed to identifying the genes that are differentially expressed between normal prostate tissue and prostate cancer. Many of such genes are believed to be nonspecific events accompanying the cancer phenotype. Only a small portion of them play a causal role in cancer development. During the funding period, we focused on mapping, identifying, and characterizing tumor suppressor genes in prostate cancer. We collected tumor cells and normal cells from a large number of specimens of prostate cancer. We then examined the genomes of these materials for chromosomal and genetic abnormalities using PCR-based methods. Completion of this project has led to the publication of six papers in biomedical journals and the award of two NIH RO 1 grants from the National Cancer Institute.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2002
Accession Number
ADA405403

Entities

People

  • Jin-Tang Dong

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Chemical Reactions
  • Chemistry
  • Chromosomes
  • Genetics
  • Genomic Instability
  • Health Services
  • Medical Personnel
  • Microsatellites
  • Neoplasms
  • Oncology
  • Polymerase Chain Reaction
  • Prostate Cancer
  • Sequence Analysis
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology