The Roles of the Y Chromosome Genes in Prostate Cancer
Abstract
Currently information regarding the contribution of the men-only chromosome, the Y chromosome, to prostate cancer is lacking. The goals of this project are designed to address this question and to identify candidate genes on the Y chromosome involved in prostate cancer. The objectives are: (1) to study the expression of Y chromosome genes in prostate cancer and (2) to evaluate their effects in over-expression in the prostate of tranagenic mice. So far, we have completed a survey on the expression of 31 Y chromosome genes in prostate cancer and have identified TSPY gene to be the most likely one to play a role in male oncogenesis. In Year 2, we have isolated and sequenced several polymorphic TSPY transcripts in normal and cancerous prostate samples, and demonstrated that over-expression of TSPY potentiates cell proliferation in vitro and tumor formation in vivo. In Year 3, we plan to address if the various TSPY isoforms have the same function in cell proliferation and to test the hypothesis on whether over-expression of TSPY in the prostate is sufficient in promoting oncogenesis in this organ using transgenic mouse strategies. These studies will provide important information on the role of this male-specific chromosome on prostatic oncogenesis and in development of new diagnostic procedures, and/or treatment for prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2002
- Accession Number
- ADA405433
Entities
People
- Chris L. Yun-fai
Organizations
- Northern California Institute for Research and Education