Investigation of the Candidate Tumor Suppressor Gene prk in Prostate Cancer
Abstract
Prostate cancer is the most common malignancy among American men. Yet our understanding of the genetic events which occur during the course of the development of this disease has lagged behind that for other common tumors. Recent studies suggest that prostate cancer appears to be driven by the mutation of as yet unknown genes. The identification of such genes should be essential to the understanding of the biology and pathology of this disease. Allelotype analysis of prostate cancer has implicated several loci of candidate tumor suppressor genes (1-3). For example, loss of heterozygosity of polymorphic markers has been identified at 7q, 8p, 10, 16q and 18q (2,3). Of these, 8p is among the most frequently lost in prostate carcinoma (1-3). Detailed analyses have defined the region of allele loss in prostate and other cancers to 8p12-21 and 8p22-pter (1,4), suggesting that the presence of two or more tumor suppressor genes at this genomic locus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2001
- Accession Number
- ADA405508
Entities
People
- David Dai