Toxic Neuronal Death by Glyceraldehyde-3-Phosphate Dehydrongenase and Mitochondria

Abstract

Apoptosis has been shown to contribute to neuronal loss in Parkinson's Disease (PD) and after a number of forms of toxic exposure. If unique elements in the signaling pathways for the PD or toxic apoptosis can be identified and their apoptosis signaling impeded, neuronal loss may be slowed or reduced in the conditions. The research proposed in this grant was designed to examine the role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in apoptotic neuronal signaling. Recent studies in postmortem brain have implicated GAPDH apoptosis signaling in Parkinson's disease (PD). Propargylamines, with structural similarity to (-)-deprenyl, bind to GAPDH and convert the protein from a tetrameric to a dimeric form in association with a decrease in apoptosis.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2001
Accession Number
ADA405517

Entities

People

  • William Tatton

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Brain
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Confocal Microscopy
  • Neurodegeneration
  • Neurons
  • Organic Chemistry
  • Proteins

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.