DNA Methylation Alterations in Breast Cancer

Abstract

We have characterized one band that exhibited a conspicuous increase in band intensity in breast cancer NotI-MseI MS-AFLP DNA fingerprints. The band contained a satellite DNA sequence in the pericentromeric regions of chromosomes. We have shown that this intensity change is frequently observed in breast cancer tissues and breast carcinoma cell lines and that it is caused by hypomethylation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA405531

Entities

People

  • Fumiichiro Yamamoto

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Artificial Satellites
  • Biological Sciences
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Chromosomes
  • Colon Cancer
  • Gene Expression
  • Genetics
  • Human Genome
  • Identification
  • Intensity
  • Methylation
  • Neoplasms
  • Sequences

Fields of Study

  • Biology

Readers

  • Atmospheric Science/Meteorology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Space