Bioactive Lipids: Role in Prostate Cancer Angiogenesis

Abstract

The first objective of phase II of this grant is to delinate the regulation of VEGF gene expression by 12-LOX in PCa cells, specifically the involvement of Sp1 and possibly AP2. The second objective of this proposal is to describe the signal transduction pathway by which 12-LOX stimulates VEGF expression. These two objectives are based upon our observations in the Phase I of this grant that that 12-LOX, when overexpressed in human PCa cells, stimulates tumor angiogenesis and growth. The third objective to evaluate the therapeutic potential of 12-LOX inhibitors for PCa treatment.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA405532

Entities

People

  • Kenneth Honn

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Biomedical Research
  • Blood
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Endothelial Cells
  • Enzyme Inhibitors
  • Gene Expression
  • Inhibition
  • Inhibitors
  • Lipids
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins

Fields of Study

  • Medicine
  • Physics

Readers

  • Prostate Cancer Biology.