Development of KGF Antagonist as a Breast Cancer Therapeutic

Abstract

This grant proposal is to synthesize potential KGF antagonists which will then be evaluated for efficacy in in vitro assay systems. The results generated for the proposed study will be useful for designing new therapeutic agent for breast cancer. KGF antagonist candidate peptides have been synthesized and evaluated its ability. There is, however lack of sensitivity issue underlies on the functional assay procedure. We then developed several KGF-receptor overexpressed cell lines for further use. We are on the process to evaluate the cell lines.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA405915

Entities

People

  • Yasuro Sugimoto

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Computer Programs
  • Deoxyribonucleic Acids
  • Growth Factors
  • Laboratory Animals
  • Materials
  • Molecules
  • Neoplasms
  • Proteins
  • Recombinant Dna
  • Structural Analysis

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Oncology (Cancer Research).