A Novel Member of the Insulin-Like Growth Factor Binding Protein Superfamily in Prostate Cancer

Abstract

The insulin-like growth factors (IGFs) are potent mitogens for normal and cancerous prostatic cells. The IGFs are found complexed to IGF binding proteins (IGFBPs), which modulate IGF bioactivity, but inay themselves act in an IGF-independent manner. We have characterized recently a series of IGFBPs in the amino-terminus, bind IGFs with low affinity, and regulate cell growth through both lOF-dependent and IGF-independent actions. This grant is directed at the study of IGFBP-rP2 (more commonly known as connective tissue growth factor) as a regulator of normal and malignant prostatic growth. The specific aims are to: 1) analyze IGFBP-rP2 mRNA and protein expression and distribution in normal and malignant prostatic tissues; 2) determine the transcriptional, translational and post-translational regulation of IGFBP-rP2; and 3) determine the mechanism by which IGFBP-rP2 regulates prostatic growth.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2002
Accession Number
ADA406049

Entities

People

  • Ron G. Rosenfeld

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Carrier Proteins
  • Cell Physiological Processes
  • Chemical Synthesis
  • Chemistry
  • Colon Cancer
  • Connective Tissue
  • Health Services
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Surface Plasmon Resonance

Readers

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