Evaluation of Chronic Stress Induced Neurodegeneration and Treatment Using and In-Vivo Retinal Model
Abstract
The role of oxidative stress in acute laser-induced retinal injury (and other retinal disease/injury modalities) has been long suspected. This study will determine the effectiveness of the snake eye/Scanning Laser Ophthalmoscope model, an in vivo, non- invasive imaging technique, for use as a longitudinal model in the study of neural injury/neurodegenerative disease. This represents a significant refinement of the model, which currently provides the unique ability to observe cellular changes in the retina. Progress has been made in three areas of research necessary to establish the snake eye as a model for human neural injury/disease: (1) A study on determining the effect of a single dose treatment with an antioxidant on temporal development of retinal laser injury, including the development of analysis techniques and lesion size quantification. The results indicate that the use of N-Acetylcysteine shows promise as a potential therapeutic tool for this type of injury. (2) The development of ocular electrophysiological techniques in this animal, and function corroboration of the cellar make up of the Great Plains rat snake retina, and (3) an analysis of the photo pigments and biochemistry of snake vision.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2002
- Accession Number
- ADA406061
Entities
People
- Andy Tain
- Heike K. Rentmeiater-bryant
- Randolph Glickman
- Rowe Elliott
Organizations
- Naval Health Research Center