A New Perspective on DCIS Using MRI: Correlation of Tumor and Vessel Proliferation with MR Signal Enhancement
Abstract
The purpose of this study is to correlate density of contrast enhancement on breast MRI images with pathology characteristics and markers of proliferation and angiogenesis in women with ductal carcinoma in situ (DCIS) of the breast. The specific aims of our study are two fold. 1) We will first develop a novel method for characterizing DCIS lesions based on cellular proliferative activity within the tumor surrounding vascular endothelium. Using immunohistochemical techniques, we will determine whether this proliferation is found in the DCIS itself, in the surrounding stroma, or in vascular endothelial cells and whether they are proximate. 2)Secondly, we will correlate this proliferative profile with MRI characteristics in order to determine whether MR can predict the biological characteristics of DCIS. Thus MR could potentially serve as a surrogate marker of biological behavior. The two aims mentioned above toward this goal we wish to acquire a better understanding of the basis and timing for transformation of DCIS which would help us to find more optimal ways to treat DCIS, and indeed, help us to treat invasive breast cancer and develop strategies for prevention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA406087
Entities
People
- E. Shelley Hwang
- Laura J. Esserman
- Nola Hylton
Organizations
- University of California, San Francisco