Relationships Between IGF-1, IGF-Binding Proteins and Diet in African American and Caucasian Men
Abstract
The study aims to determine racial differences between insulin-like growth factor-I (IGF-1), insulin-like binding protein -2 (IGFBP-2), insulin-like binding protein-3 (IGFBP-3), prostate specific antigen (PSA), testosterone, body mass index (BMI), and diets high in calories, protein and fat. Specifically, the study objectives are to: 1) define racial differences in serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, and testosterone; 2) define how diet and BMI impact serum levels of IGF-1, IGFBP-2, IGFBP-3, testosterone and PSA in African American and Caucasian men; and 3) determine the associations between serum levels of free and total IGF-1, IGFBP-2, IGFBP-3, testosterone, PSA, BMI and specific nutrients. The proposed study will help to explain the increased risk of prostate cancer for African American men and the role of specific nutrients in influencing IGF-1 and IGF-binding protein concentrations. This report covers primarily patient accrual activities during the first and second year of the project. These activities include finalizing the clinical protocol, hiring and training of study personnel, reviewing clinical questionnaires to determine study eligibility, and determination of stored frozen samples for use. A total of 544 men were recruited to participate in the study. Approximately 599 assays have been analyzed for IGF- 1, IGFBP-2, and IGFBP-3. A total of 100 men were stratified and randomized for the telephone interview. Of this number, 25 men were interviewed to determine nutritional intake.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2002
- Accession Number
- ADA406111
Entities
People
- Tanya Agurs-collins
Organizations
- Howard University