Analysis of Genes Differentially Expressed in a Human Ovarian Cancer Model

Abstract

Most epithelial cell cancers (cervix, colon, skin, prostate, breast, etc.) develop from precursor lesions resulting from an accumulation of mutations in growth regulatory genes. Such precursor lesions have not been identified for OVCA but it has been proposed that OVCAs arise by a multistep process through increasingly aggressive stages. We have shown that immortalized human ovarian surface epithelial (HOSE) cells undergo stepwise progression to the malignant phenotype in vitro. We now hypothesize that this phenotypic presentation reflects changes in the expression of genes in biochemical pathways required for transition from benign cells to malignantly transformed cells. The long-range goal of these studies is to identify aberrantly expressed genes in NOSE cells at various stages along the path to the malignant phenotype for the pur%)ose of characterizing biochemical pathways whose expression is dysregulated.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2002
Accession Number
ADA406122

Entities

People

  • Wayne D. Lancaster

Organizations

  • Wayne State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cancer
  • Cells
  • Culture Techniques
  • Dna Microarrays
  • Electronic Mail
  • Epithelial Cells
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Genetics
  • Microarray Analysis
  • Neoplasms
  • Ovarian Cancer
  • Phenotypes

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).