Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells

Abstract

The long range goal of this laboratory is to identify integrin-associated signaling events that contribute to the constitutive migration of human breast cancer cells on the laminin extracellular matrix proteins. This project has shown that the heterotrimeric G-protein Galphai3 may link integrin activation and migration of MCF-lOA cells via a cAMP signaling pathway. The focus of the remaining work on this project is to identify how each integrin subtype which binds laminin-1 contributes to the regulation of this and other pro- migratory signaling pathways.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2002
Accession Number
ADA406136

Entities

People

  • William L. Rust

Organizations

  • University of Nevada, Las Vegas

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Medical Personnel
  • Organic Chemistry
  • Proteins

Fields of Study

  • Biology
  • Chemistry

Readers

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