Study of the Regulation of erbB Signaling by Receptor-Mediated Endocytosis

Abstract

The purpose of my project remains the same. In the paper Vieira et al. (1996), it was demonstrated that endocytosis of EGF receptors (EGFR) played a role in the regulation of their signaling. EGFR is internalized following its activation and dimerization with a second receptor. A second receptor that is internalization-impaired, such as erbB-2, would presumably slow down internalization of EGFR. Internalization and down-regulation of receptors is the mechanism by which cells control signaling from EGFR. Inhibition of endocytosis leads to persistence of the activated receptors on cell surface and increases the duration and strength of signaling from EGFR, which may lead to unregulated cell growth and transformation. My plan is to show that erbB-2 does indeed affect EGFR endocytosis, and this will lead to alteration of downstream signaling. By making mutations in the regulatory cytoplasmic tail of erbB-2, I could potentially enhance its capability for endocytosis, and this should restore normal signaling to EGFR.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA406140

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  • Anthony Lee

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  • University of Pennsylvania

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