Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides With Different Half Lives
Abstract
The objective of the project is to test whether the therapeutic effectiveness of permanent implant brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. A theoretical model for continuous low dose rate irradiation using a mixture of radionuclides has been developed. Experiments have been performed using BAll12 tumor cells and Chinese Hamster cells growing in vitro and BAlll2 cells growing in vivo as solid tumors in WAG/rij rats. Radiobiology parameters for these cells have been determined and used in the theoretical radiobiology model to improve our understanding of the experimental observations. We have designed and fabricated applicators for in vivo irradiations as well as developed the animal care procedures. We have performed in vivo experiments for tumor growth studies using the BAlll2 rat model with 1251 seed applicators. Further experiments with 103Pd and mixed radionuclides are in progress. The in vivo studies with the rat model have been very difficult to perform because of the nature of these brachytherapy experiments, which involve long irradiation times. We would focus on completing the studies using the rat model in the next year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2002
- Accession Number
- ADA406180
Entities
People
- Ravinder Nath
Organizations
- Yale University