Cellular and Molecular Changes of the Respiratory System in Rats Exposed to ACM Combustion
Abstract
The use of ACM in the military and private sector is increasing. Yet little is known concerning the toxicity of the byproducts of ACM combustion. Recently, as a result of accidents and mishaps, significant interest has developed regarding the potential health hazards associated with the combustion of ACM and the release of toxic gases, vapors and particles. We hypothesize that exposure to such atmospheres result in cellular and molecular alterations that ultimately may lead to lung injury. Smoke inhalation is one of a number of conditions that can result in the development of adult respiratory distress syndrome (ARDS), a severe form of lung injury that carries with it significant mortality. We propose to investigate the cellular and molecular changes of the respiratory system in rats exposed to ACM combustion atmospheres. By identifying the critical pathways necessary for the development of lung injury from ACM combustion atmospheres, we could apply that knowledge toward new and improved methods of treatment for lung injury including ARDS. In addition, by investigating the cellular and molecular changes prior to lung injury, we may be able to identify biomarkers that would be early predictors of those individuals at risk for progression to lung injury following exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2001
- Accession Number
- ADA406210
Entities
People
- Paul Reinhart
Organizations
- Naval Health Research Center