Use of Novel Technologies to Identify and Investigate Molecular Markers for Ovarian Cancer Screening and Prevention
Abstract
The purpose of this study is to identify novel genes that encode proteins that can be used to detect ovarian cancer before it spreads outside the ovary and becomes incurable. The goal is to assemble a panel of known and novel ovarian tumor markers that may form the basis of a cost-effective, serologic screening test for early stage ovarian tumors. The research encompasses the use of two novel technologies to identify such genes. In Project 1 we use HDAH to identify genes that are over-expressed in ovarian cancer tissue. In Project 2 novel ovarian tumor antigens are being identified by SEREX. We have identified a large number of genes that are over-expressed in ovarian cancer tissue relative to the ovarian tissue obtained from women without cancer or ovarian pathology. We have also identified several oncogenic proteins that elicit antibodies detectable in the blood of some ovarian cancer patients. These discoveries provided the foundation for ongoing work in early detection of ovarian cancer, funded by the NCI as part of a SPORE in ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA406232
Entities
People
- Nicole D. Urban