Characterization of Genetic Alterations in Ovarian Cancer
Abstract
Ovarian cancer is a highly lethal malignancy specific to women. We have set up the infrastructure at Mayo for an Ovarian Cancer Research Program utilizing the rich resources of clinical material. This Program Project focuses specifically upon a genetic analysis of ovarian cancer using the transcriptional profiling strategies of cDNA microarrays and subtraction suppression hybridization. We have linked the work of cancer geneticists with cell biologists to begin to understand the functional role that some of the consistently aberrantly-regulated genes play in ovarian cancer development. There are three projects in this grant. The first project focuses on the identification of consistently down-regulated genes in ovarian cancer. The second project focuses on the role of gene amplification in familial versus sporadic ovarian cancer. The third project is to characterize genes that are consistently down-regulated in ovarian tumors that are derived from within common fragile site regions. This Program Project is centered within a larger institutional effort to better understand the biology of the development of ovarian cancer and to devise better strategies for the prevention, early detection, and treatment of this lethal disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA406237
Entities
People
- David I. Smith
Organizations
- Mayo Clinic